Investigators dedicated to researching Hereditary Spastic Paraplegia (HSP) and Primary Lateral Sclerosis (PLS) from around the United States have come together to create critical resources for the HSP and PLS community. The SP-CERN (Spastic Paraplegia Centers of Excellence Research Network) establishes a network of ten initial centers in North America. Dr. Shy and UIHC are now part of this group.